Pharmacology & Toxicology Faculty
I started my research program on the role of lipid rafts as compartments for signaling via neurotrophin receptors. As changes in neurotrophin signaling are known to contribute to nerve degeneration in diabetic neuropathy, we extended our work to diabetic animal and cell culture models, which is the current thrust in the lab.
Over the years, I have devoted my energies to training undergraduate, graduate, and post-doctoral associates to become highly respected neuroscientists, neuropharmacologists, or neurobehavioral scientists.
The specific aims of my research are designed to determine how the Msr system affects the function and expression of other proteins as well as to evaluate the role of methionine oxidation in the progression of oxidative stress and age related diseases.
I received a Ph.D. in biophysics with a specialization in oxidative stress research and have been conducting research in the field of oxidative stress since my graduation.
Dr. Xinkun Wang earned a B.S. in 1994, and an M.S. in 1997, in Biology from Sichuan University in Chengdu, China, and a Ph.D. in Plant Molecular Biology from Oklahoma State University in 2003. After joining KU, he has also been serving as the director of KU Genomics Facility and Genome Sequencing Core.
Research conducted in Dr. Yan’s laboratory is geared toward unraveling the cellular and molecular basis of neurodegeneration and devising therapeutic strategies to hamper the processes that cause neuronal death.