Jeff Krise

  • Associate Professor
  • School of Pharmacy - Pharmaceutical Chemistry
785-864-2626
Office
Simons Biosciences Research Laboratories, Room 236-B
University of Kansas
2095 Constant Avenue
Lawrence, KS, 66047

Education

  • Postdoctoral, Department of Biochemistry, Stanford University School of Medicine, Stanford, CA (1998 - 2001)
  • Postdoctoral, Victorian College of Pharmacy (now Monash University), Melbourne, Austrailia
  • Ph.D. (w/honors), Pharmaceutical Chemistry, University of Kansas, Lawrence, KS (1998)
  • B.S., Pharmacy, Duquesne University, Pittsburgh, PA (1993)

Experience

Professional Experience

  • Associate Professor, University of Kansas, Department of Pharmaceutical Chemistry (2004 - present)
  • University of North Carolina at Chapel Hill, Division of Drug Delivery (2001)

Research Overview

The Krise laboratory seeks to understand how drugs distribute and localize within human cells and how this influences their therapeutic activity and pharmacokinetic distribution properties. Much of our recent studies have focused on the intracellular distribution of amine-containing drugs and their propensity to become highly concentrated in acidic intracellular compartments such as lysosomes according to an ion trapping-type mechanism.

Research Interests

  • Drug delivery
  • Pharmacokinetics
  • Prodrugs
  • Intracellular

Events
2nd among all schools of pharmacy in National Institutes of Health funding
Brings more than $20 million in external funding into the state each year
7 of 19 cancer drugs formulated through the National Cancer Institute were developed at the KU School of Pharmacy
3,000 free flu shots given to Kansans in need during the past 5 years
4,000 living alumni, 63 percent of them living and working in Kansas
KU pharmacists practice in 95 of Kansas’ 105 counties
20th among public schools of pharmacy.
—U.S. News & World Report
$20.2 million NIH research grant earned by Distinguished Professor Jeff Aubé was 2nd largest in Kansas history
100 percent placement after graduation for KU Pharm.D. students
Established in 1885 as the 1st professional program at KU