Honglian Shi

  • Associate Professor
  • Director of Graduate Studies, Pharmacology & Toxicology
  • School of Pharmacy - Pharmacology & Toxicology
785-864-6192
Office
Malott Hall, Room 5044
University of Kansas
1251 Wescoe Hall Drive
Lawrence, KS, 66045

Education

  • Postdoctoral Fellow, Tokyo University and Burke Medical Research Institute, Cornell University Medical College
  • Ph.D. Biophysics, Institute of Biophysics, CAS, Beijing, China (1995)

Biography

Honglian Shi received a Ph.D. in biophysics with a specialization in oxidative stress research and has been conducting research in the field of oxidative stress since his graduation. Oxidative stress results from the imbalance between free radical production and the antioxidant defense in cells. The stress has been implicated in the process of aging and the pathogeneses of more than sixty pathological conditions including neurodegenerative diseases, stroke, heart disease, cancers, and diabetes. He has broad interests in free radical metabolism and the mechanisms of free radicals in diseases and aging, aiming at understanding the interactions between free radicals and other cellular molecules and finding efficient and specific treatments. For example, cerebral ischemia has tremendous effect on free radical metabolism due to the changes in the levels and metabolism of oxygen and glucose. One of the ongoing projects is to understand the changes of free radical generation and small redox metabolites such as glutathione, their functions in regulating transcription factors, and their roles in cell death and survival in ischemic conditions in the brain. Another is to understand the mechanism of heavy metal induced-tissue injuries in the brain and carcinogenesis. This research is being pursued with multidisciplinary approaches including biochemistry, biophysics, neuroimaging, and molecular biology.

Publications

Selected Publications

Zhang, Z. Yan, J. & Shi, H. (2016). Role of Hypoxia Inducible Factor 1 in Hyperglycemia-Exacerbated Blood-Brain Barrier Disruption in Ischemic Stroke. Neurobiology of disease, 95, 82-92. DOI:10.1016/j.nbd.2016.07.012


Events
2nd among all schools of pharmacy in National Institutes of Health funding
Brings more than $20 million in external funding into the state each year
7 of 19 cancer drugs formulated through the National Cancer Institute were developed at the KU School of Pharmacy
3,000 free flu shots given to Kansans in need during the past 5 years
4,000 living alumni, 63 percent of them living and working in Kansas
KU pharmacists practice in 95 of Kansas’ 105 counties
20th among public schools of pharmacy.
—U.S. News & World Report
$20.2 million NIH research grant earned by Distinguished Professor Jeff Aubé was 2nd largest in Kansas history
100 percent placement after graduation for KU Pharm.D. students
Established in 1885 as the 1st professional program at KU