Jackob Moskovitz

  • Associate Professor
  • School of Pharmacy - Pharmacology & Toxicology
785-864-3536
Office
Malott Hall, Room 5003
University of Kansas
1251 Wescoe Hall Drive
Lawrence, KS, 66047

Education

  • Postdoctoral Training - Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ; Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
  • D.Sc., Unit of Biochemistry, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel (1992)

Biography

Jackob Moskovitz research is aimed at determining how the Msr system affects the function and expression of other proteins and evaluating the role of methionine oxidation in the progression of oxidative stress and age-related diseases.

Research Overview

Oxidative damage to proteins is considered to be one of the major causes of aging and age-related diseases, and thus mechanisms have evolved to prevent or reverse these modifications. Methionine is one of the major targets of reactive oxygen species (ROS), where it is oxidized to methionine sulfoxide (MetO). Recently evidence has accumulated suggesting that methionine oxidation may play an important role in the progression of neurodegenerative diseases like Alzheimer's and Parkinson's disease. Oxidative alteration of Met to Met(O) is reversed by the methionine sulfoxide reductases (MsrA which reduces S-MetO and MsrB which reduces R-MetO). This may prevent irreversible protein damage and as a consequence extend the organism's life span. A major biological role of Msrs is suggested by the fact that the MsrA null mouse (MT) exhibits a neurological disorder in the form of ataxia ("tip toe walking"), is more sensitive to oxidative stress, and has a shorter life span (by~40%) than wild-type (WT) mice. However, a major open question is how these important antioxidants function, and is the methionine oxidation/reduction cycle analogous to the cysteine oxidation/reduction or protein-phosphorylation / dephosphorylation mechanisms involved in cell signaling. The specific aims of Jackob Moskovitz's research is designed to determine how the Msr system affects the function and expression of other proteins as well as to evaluate the role of methionine oxidation in the progression of oxidative stress and age related diseases.

Research Interests

  • Oxidation-Stress in Aging and Neurodegenerative Diseases
  • Receptors of Neurotransmitters
  • Methionine Sulfoxide Reductase System
  • Methionine Oxidation
  • Post-Translational Modifications
  • Protein-Degradation
  • Signal Transduction

Events
2nd among all schools of pharmacy in National Institutes of Health funding
Brings more than $20 million in external funding into the state each year
7 of 19 cancer drugs formulated through the National Cancer Institute were developed at the KU School of Pharmacy
3,000 free flu shots given to Kansans in need during the past 5 years
4,000 living alumni, 63 percent of them living and working in Kansas
KU pharmacists practice in 95 of Kansas’ 105 counties
20th among public schools of pharmacy.
—U.S. News & World Report
$20.2 million NIH research grant earned by Distinguished Professor Jeff Aubé was 2nd largest in Kansas history
100 percent placement after graduation for KU Pharm.D. students
Established in 1885 as the 1st professional program at KU