Associate Professor Apurba Dutta earned a Ph.D. from North-Eastern Hill University in Shillong, India in 1989 and was a post-doctoral fellow at the University of Konstanz in Germany from 1991-1992. He was also a post-doctoral fellow at the University of Kansas from 1993-1994.
- Medicinal agents
- Principles of drug design
Organic Synthetic (including combinatorial synthesis) and Medicinal Chemical studies of bioactive compounds of natural and non-natural origin.
Biological research targets include, Proteasome (anti-cancer), Sphingolipids (anti-cancer), Chitin synthase (anti-fungal), HIV (anti-viral), and Endotoxin (anti-sepsis / anti-bacterial).
The compound classes of interest include, nucleosides, amino acids / peptides, carbohydrate / carbohydrate mimics, alkaloids, lipopolyamines, and aza-heterocyclics
Pashikanti, S., Ukani, R., David, S. A, & Datta, A. (2017). Total Synthesis and Structure-Activity Relationship Studies of the Cytotoxic Anhydrophytosphingosine Jaspine B (Pachastrissamine). Synthesis, 49(9), 2088-2100. DOI:10.1055/s-0036-1588118 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1588118
Foster, A. C, Li, Y., Runyan, S., Dinh, T., Venadas, S., Chen, J., Pashikanti, S., Dutta, A., Ehring, G., & Staubli, U. (2016). Activity of the enantiomers of erythro-3-hydroxyaspartate at glutamate transporters and NMDA receptors.
Datta, A. (07/25/2015 - 07/25/2015). A serine-derived second-generation chiron: Applications in the synthesis of drug-like molecular scaffolds. India Global Pharma Expo & Summit 2015 (IGPES-2015). Hyderabad, India
Dutta's research areas include asymmetric total synthesis of natural and non-natural compounds of biomedical significance (anti-infectives and anti-cancer), and development of new organic synthetic methodologies.