James W. Tracy

School of Pharmacy - Pharmacology & Toxicology
Professor
Primary office:
785-864-0975
Malott Hall
Room 2040
University of Kansas
1251 Wescoe Hall Drive
Lawrence, Kansas 66045


Education

PhD, Biochemistry, Purdue University

BS, Chemistry, Bowling Green State University

Research

The biochemistry of the human trematode parasite Schistosoma mansoni and the chemotherapy of schistosomiasis, the disease it causes, has been the primary research focus of my research for the past twenty-five years. Early on I studied the role of parasite egg antigens in the pathogenesis of schistosomiasis and the mechanism of action of the antischistosomal drug niridazole. After arriving at the University of Wisconsin, my laboratory turned its attention to studying the enzymes of drug metabolism in schistosomes. We investigated schistosome glutathion S-transferases and demonstrated that conjugation with glutathione is a pathway of xenobiotic conjugation in these organisms. Work from our laboratory and others established the importance of glutathione and glutathione S-transferases as cellular defense mechanisms in parasites.

More recently we discovered quite by chance the schistosome homologue of a yeast protein, Mak16p, that plays an essential, but undefined role in regulating biogenesis of 60S ribosomal subunits. Mak16 has since been found in every eukaryotic species examined. Its protein sequence contains both nuclear localization sequences and nucleolar retention signals, consistent with a role in ribosome biogenesis, and a highly conserved cluster of cysteine residues that is essential for function. Because schistosomes are not amenable to genetic manipulation, our most recent work used the yeast Saccharomyces cerevisiae as a model organism.

Because my administrative duties occupied an inordinate amount of time, I concluded it was no longer possible to provide adequate mentoring to graduate students and postdocs. I suspended active research at the end of 2004.


Contact Advisor
2nd among all schools of pharmacy in National Institutes of Health funding
Brings more than $20 million in external funding into the state each year
7 of 19 cancer drugs formulated through the National Cancer Institute were developed at the KU School of Pharmacy
3,000 free flu shots given to needy Kansans during the past 5 years
4,000 living alumni, 63 percent of them living and working in Kansas
KU pharmacists practice in 95 of Kansas’ 105 counties
20th among public schools of pharmacy.
—U.S. News & World Report
$20.2 million NIH research grant earned by Distinguished Professor Jeff Aubé was 2nd largest in Kansas history
100 percent placement after graduation for KU Pharm.D. students
Established in 1885 as the 1st professional program at KU
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