Apurba Dutta

School of Pharmacy - Medicinal Chemistry
Associate Professor
Primary office:
785-864-4117
Malott Hall
Room 4001
University of Kansas
1251 Wescoe Hall Drive
Lawrence, KS 66045-7582


Associate Professor Apurba Dutta earned a Ph.D. from North-Eastern Hill University in Shillong, India in 1989 and was a post-doctoral fellow at the University of Konstanz in Germany from 1991-1992. He was also a post-doctoral fellow at the University of Kansas from 1993-1994.

 

Teaching Interests

  • Medicinal agents
  • Principles of drug design

Research

Organic Synthetic (including combinatorial synthesis) and Medicinal Chemical studies of bioactive compounds of natural and non-natural origin.

Biological research targets include, Proteasome (anti-cancer), Sphingolipids (anti-cancer), Chitin synthase (anti-fungal), HIV (anti-viral), and Endotoxin (anti-sepsis / anti-bacterial).

The compound classes of interest include, nucleosides, amino acids / peptides, carbohydrate / carbohydrate mimics, alkaloids, lipopolyamines, and aza-heterocyclics

Selected Publications

Pashikanti, S., Ukani, R., David, S. A, & Datta, A. (2017). Total Synthesis and Structure-Activity Relationship Studies of the Cytotoxic Anhydrophytosphingosine Jaspine B (Pachastrissamine). Synthesis, 49(9), 2088-2100. DOI:10.1055/s-0036-1588118 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1588118

Foster, A. C, Li, Y., Runyan, S., Dinh, T., Venadas, S., Chen, J., Pashikanti, S., Dutta, A., Ehring, G., & Staubli, U. (2016). Activity of the enantiomers of erythro-3-hydroxyaspartate at glutamate transporters and NMDA receptors.

Selected Presentations

Datta, A. (07/25/2015 - 07/25/2015). A serine-derived second-generation chiron: Applications in the synthesis of drug-like molecular scaffolds. India Global Pharma Expo & Summit 2015 (IGPES-2015). Hyderabad, India

Dutta's research areas include asymmetric total synthesis of natural and non-natural compounds of biomedical significance (anti-infectives and anti-cancer), and development of new organic synthetic methodologies.


Contact Advisor
2nd among all schools of pharmacy in National Institutes of Health funding
Brings more than $20 million in external funding into the state each year
7 of 19 cancer drugs formulated through the National Cancer Institute were developed at the KU School of Pharmacy
3,000 free flu shots given to needy Kansans during the past 5 years
4,000 living alumni, 63 percent of them living and working in Kansas
KU pharmacists practice in 95 of Kansas’ 105 counties
20th among public schools of pharmacy.
—U.S. News & World Report
$20.2 million NIH research grant earned by Distinguished Professor Jeff Aubé was 2nd largest in Kansas history
100 percent placement after graduation for KU Pharm.D. students
Established in 1885 as the 1st professional program at KU
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