Over the years, I have devoted my energies to training undergraduate, graduate, and post-doctoral associates to become highly respected neuroscientists, neuropharmacologists, or neurobehavioral scientists.
I have taught on a broad range of topics in the neurosciences, neurobiology, neurochemistry, neuropharmacology, basic pharmacological principles, pharmacology of anti-infective agents. I have taught both undergraduate and graduate courses over many years at the University of Kansas, both in the College of Liberal Arts and Sciences and in the School of Pharmacy. For the most part, students felt that they were exposed to interesting and new material and liked both the style and content of my lectures or discussions.
- Pharmacology, Antibiotics Neuroscience, Neurochemistry, Neurotransmission, Channel Characteristics
The primary areas of my research interests are: (1) Purification, molecular characterization, cloning and expression of receptors for the excitatory amino acid L-glutamic acid and related amino acids; (2) development of cellular and molecular systems for the characterization of new drugs that act on the excitatory amino acid receptors; (3) exploration of the activity of transport carriers, enzymes and receptor-regulated ion channels in brain synaptic membranes; (4) reconstitution of isolated membrane receptors and ion channels and determination of activated channel responses; (5) determination of the effects of ethanol on synaptic membrane glutamate receptor and calcium transport activities; (6) development of programmatic research on the molecular genetics of alcoholism, including the development of transgenic mice; (7) determination of molecular mechanisms for neurodegeneration; (8) characterization of the effects of oxidative stress on receptor function and signal transduction in neurons; (9) characterization of molecular and cellular events associated with aging and Alzheimer’s disease and other neurodegenerative diseases.
- Neurotransmission, Glutamate, Receptors, Alcoholism, Aging, Neurodegeneration, Oxidative Stress
My career at the University of Kansas is fairly replete with service and administrative duties that I have fulfilled.
Badawi, Y. (2015). Ischemic tolerance in an in vivo model of glutamate preconditioning. Journal of Neuroscience Research, 93(4), 623–632. DOI: 10.1002/jnr.23517 http://onlinelibrary.wiley.com/doi/10.1002/jnr.23517/epdf
Wang, X. (2014). Gene Expression Patterns in the Hippocampus during the Development and Aging of Glud1 (Glutamate Dehydrogenase 1) Transgenic and Wild Type Mice. BMC Neuroscience, 15(1). DOI:10.1186/1471-2202-15-37 http://www.biomedcentral.com/content/pdf/1471-2202-15-37.pdf http://www.biomedcentral.com/content/pdf/1471-2202-15-37.pdf
Wilkins, H. M (2014). Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. Hum. Mol. Genet., 23(24), 6528-6541. DOI: 10.1093/hmg/ddu371 http://hmg.oxfordjournals.org/content/23/24/6528.long
Choi, I. Y, Lee, P., Wang, W. T, Hui, D., Wang, X., Brooks, W. M, & Michaelis, E. K (2014). Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice. Neurochemical research, 39(3), 446-55. DOI:10.1007/s11064-014-1239-9