Brian Scott Blagg

School of Pharmacy - Medicinal Chemistry
Professor
Primary office:
786-864-2288
Malott Hall
Room 5047
University of Kansas
1251 Wescoe Hall Drive
Lawrence, KS 66045


Professor Brian Blagg earned a B.A. in chemistry and environmental studies in 1994 from Sonoma State University and a Ph.D. in organic chemistry in 1999 from the University of Utah. In 2002, Blagg completed an NIH Postdoctoral Fellow at The Scripps Research Institute.

 

Research Interests

  • Design, synthesis, and evaluation of Hsp90 inhibitors as anti-cancer agents
  • Biological characterization of Hsp90 inhibitors against colon, breast, and prostate cancers
  • Development of novel chaperone inhibitors/regulators for the treatment of neurodegenerative diseases
  • Development of assays for characterization of Hsp90 inhibitors

The primary goals of the Blagg Research Team are to design, synthesize, and evaluate novel inhibitors of the Hsp90 protein folding process. To achieve these goals, they use computer modeling to design new molecules to bind to these ATP binding sites, develop new organic reactions that allow access the desired compounds in a highly efficient manner, and finally, develop assays that are suitable for determining the biological effects of our rationally designed Hsp90 inhibitors. They are engaged in more than 30 collaborative studies with researchers throughout the world.


Events
KU Today
2nd among all schools of pharmacy in National Institutes of Health funding
Brings more than $20 million in external funding into the state each year
7 of 19 cancer drugs formulated through the National Cancer Institute were developed at the KU School of Pharmacy
3,000 free flu shots given to needy Kansans during the past 5 years
4,000 living alumni, 63 percent of them living and working in Kansas
KU pharmacists practice in 95 of Kansas’ 105 counties
20th among public schools of pharmacy.
—U.S. News & World Report
$20.2 million NIH research grant earned by Distinguished Professor Jeff Aubé was 2nd largest in Kansas history
100 percent placement after graduation for KU Pharm.D. students
Established in 1885 as the 1st professional program at KU